How do two cells that can adhere, decide whether or not they should adhere? Typically, potentially adherent cells become adherent by increasing their adherence-receptor expression levels (R1/R2) past a certain “threshold” or “EC50” (see figure above). A classic 1984 paper defined this EC50 as a function of R1/R2‘s binding constant Ksoln as illustrated above for two average eukaryotic cells.1,2 This equilibrium model for cellular adhesion is described in more detail below.
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